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9,510 Pharmacokinetic limitations, off-target effects, and patient-to-patient variability further contribute to inconsistent clinical trial results

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However, mutation of the active cysteine residue induces a significant loss of catalytic efficiency as well as GSH binding affinity at the G-site 19,20,21

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In some laboratory animals, such as the rat and guinea pig, much of it is acetylated prior to export from the intestines