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npj Science of Learning

These nanosystems offer a transformative platform for enhancing the pharmacological and biopharmaceutical performance of various drugs, including GLP-1 receptor agonists, which are otherwise limited by poor oral bioavailability, enzymatic degradation, and rapid renal clearance

213 It also downregulates inflammatory cytokines, including TNF- and IL-6, through the SIRT1NF-B axis, mitigating chronic inflammation

3.4 Direct regulatory mechanisms of gut microbiota-derived metabolites on Core clock genes in hepatocytes The autonomous oscillatory loop composed of core clock genes in hepatocytes serves as the primary regulator of hepatic metabolic rhythms