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The answer: it depends and everything we know comes from animal models

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Reduced iHSP72 levels in skeletal muscle and other insulin-responsive tissues are strongly associated with insulin resistance, a defining feature of T2DM

NO has temporal effects on beta-cell responses, as early and transient levels of NO (less than 24 hours) facilitate the repair of cytokine-induced DNA damage by inhibiting the activation of the DNA damage response and preventing the induction of apoptosis (90)