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The STEP trials (20212023) demonstrated that semaglutide produces 1522% body-weight loss over 68 weeks when combined with lifestyle changes, compared to 23% weight loss with placebo

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You need to consume enough fluids at the correct times to get good hydration, namely during hot weather or right after activities

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No published study has tested this split approach directly, but the pharmacological logic holds: maximize both local concentration and systemic delivery

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