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According to NICE Clinical Knowledge Summary guidance, patients with neurological involvement should receive more intensive initial treatment to optimise recovery potential

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On top of their action at a transcriptional level, literature recently highlighted the potential of (poly)phenols to exert some post-transcriptional regulation of genes through the modulation of non-coding RNAs expression, called microRNAs (miRNAs), which can behave as gene regulators (Reference Milenkovic, Deval and Gouranton88,Reference Milenkovic, Jude and Morand89)

"The effect of alpha-lipoic acid on inflammatory markers and body composition in obese patients with non-alcoholic fatty liver disease." J Clin Pharm Ther

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(trusted non-journal) National Institutes of Health