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Patient selection criteria are not well-established, and determining which patients are most likely to benefit from these therapies requires clinical judgment based on limited evidence

Phase 3 trials for obesity drugs typically run 72 to 96 weeks, and the FDA review process adds another 6 to 12 months after submission

Consequently, promising interventions often fail to demonstrate meaningful clinical impact, revealing the limitations of current models and endpoint [566]

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Reduced glutathione (GSH) is the active antioxidant species that directly scavenges reactive oxygen species and free radicals, while oxidized glutathione (GSSG) is formed when two GSH molecules are linked via a disulfide bond after oxidation