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Kurita M, et al

One lingering obstacle to broader use is limited supply of the drug, which has been in shortage for more than a year, according to the FDA

Petrelintide: Human amylin analog for weight management Late-breaking data from the Phase II ZUPREME-1 trial will highlight the efficacy and safety of petrelintide, an investigational human amylin analog being evaluated for weight management in people living with overweight and obesity

Clinical studies published in The Lancet show that both formulations produce significant weight loss, though the injectable version has historically delivered slightly higher average reductions