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To date, the implementation of endgame interventions has been minimal and, consequently, the evidence base of their potential effects is weak.18 For example, none of the endgame interventions included in the A/NZ Action Plan have been implemented at country level, with the possible exception of substantial reductions in retail supply in Hungary

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Specific actions involve blocking signaling pathways such as transforming growth factor- (TGF-) and cyclic adenosine monophosphate/protein kinase A (cAMP/PKA), reducing ECM synthesis by inhibiting synthases, and modulating inflammatory mediator secretion to alleviate inflammatory responses (146, 147)