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Cerulein, an orthologue of the hormone cholecystokinin (CCK), is given to isolated cells or animals in supraphysiologic concentrations (10-100x that required to induce physiological responses), to induce experimental pancreatitis

This is thanks to dopamine, the neurotransmitter that powers the brains desire circuit, triggering energy, enthusiasm, and motivation for the future

Although it was freshly tinned this tobacco smoked like a xmas cheer that had a chance to ferment for a few years

You're not just getting "sweet" or "cool." You're getting layers: roasted bitterness, nutty undertones, a hint of caramel, sometimes even a tobacco-like richness that feels familiar and grounding

January 12, 2009