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Of these substances, alcohol and tobacco use among the general population stands out, although the use of other substances, in particular hypnotics and illegal drugs, is also a cause for concern

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One of the first glaring impacts is that as more and more cigarettes are sold outside of legal means, standard controls like age restrictions are less stringent

These comparisons highlight one of the most important limitations of this study: we had no precise objective measure of smoking, no absolute Gold Standard against which to evaluate self-reports