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More recently, the perception of risk of e-cigarettes as being as harmful as cigarettes has become common, and mostly likely a consequence of the considerable media attention focused on youth gateways to smoking or to addiction (McNeill et al., 2020)

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The loose skin under their eyes is typical for smokers, according to Bahman Guyuron, MD, of Case Western Reserve University

FeNO is an essential marker of eosinophilic airway inflammation, and reduction in its levels may be due to rapid conversion of nitric oxide to peroxynitrite by reactive oxygen and nitrogen species or downregulation of nitric oxide synthase [113, 114]