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3.5.2.4 Impact of smoking on prognosis As described above in Section 3.5.1.4, smoking is associated with poor treatment outcomes and higher risk of dying from head and neck cancers (oral, nasal, sinus, laryngeal and pharyngeal cancers)

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Deletion of Nrf2 abrogated the protective effects of AZI in vitro and in vivo To further confirm the role of Nrf2 in AZI-ameliorating airway epithelial barrier dysfunction, lentiviral-delivered shRNAs was used to knock down Nrf2 expression in HBECs