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"Tobacco-specific nitrosamines, some of the chemical compounds in thirdhand smoke, are among the most potent carcinogens there are." A January paper in PLOS ONE that used mice to assess the health hazards highlighted the knowledge gap: Although the potential risks attributed to [thirdhand smoke] exposure are increasing, virtually nothing is known about the specific health implications of acute or cumulative exposure

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Virginia forms the base of many tobacco blends