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Another approach would be to adopt policies rooted in harm reduction, such as encouraging smokers to switch to lower-risk alternatives, like e-cigarettes, snus, or heated tobacco products

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Among studies including only two time points that addressed smoking progression, those that did not eliminate baseline ever smokers and used an alternate strategy for addressing reverse causation (e.g., statistical adjustment of baseline combustible tobacco use, elimination of baseline current combustible tobacco users without eliminating baseline past combustible tobacco users) were considered to provide less robust evidence of temporal precedence of an association of e-cigarette use with smoking progression (Etter, 2017)

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