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As demonstrated by the enclosed collection of Natural American Spirit brand ads, covering the period 2000-2015, the company long has used the terms natural tobacco, organic tobacco and 100% additive-free to describe its cigarettes

Additionally, use of higher dose formulations appears to be safe and more effective

Due to policies implemented between 1998 and 2016, it achieved a reduction of 37.7% for males and 38.5% for females, relative to the levels that they would have been if policies were held at the1998 level

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However, the method does come with drawbacks, including potential respiratory irritation and the need to smoke in appropriate settings

The medication is not approved for people under 18 years of age, as safety and effectiveness have not been established in poediatric populations