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Dehydration and Dry Mouth: Both alcohol and marijuana can lead to dehydration and a sensation known as "cottonmouth," or dry mouth

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Nicotine comprises a generous 0.3-0.5% of the plants weight by dry volume, being synthesized naturally by the roots, and later being shuttled to and concentrating in the plants leaves

Annu Rev Med 65:245261 Kalkhoran S, Glantz SA (2015) Modeling the health effects of expanding e-Cigarette sales in the United States and United Kingdom: a Monte Carlo analysis