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The Medical Research Council found in a study that for every R1 the government received from taxes on cigarettes, R2 was spent on treating illnesses caused by tobacco and on loss of productivity

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Nicotine exposure gives rise to differential gene expression of endothelial cells, growth of atherosclerotic plaques, and angiogenesis [111, 112]

Cigarette smoke stimulates alveolar macrophages and dendritic cells to produce chemokines such as macrophage-derived chemokine and thymus- and activation-regulated chemokine, which recruit eosinophils into the lungs [24]