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Not consenting or withdrawing consent, may adversely affect certain features and functions

The sample consisted of 18% marijuana-only smokers, 20% tobacco-only smokers, and 24% marijuana and tobacco smokers, and 38% non-smokers

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Second, we did not apply additional pleiotropy-robust methods such as MR-PRESSO, which could help identify and correct for potential outlier variants, and thus we cannot completely rule out the presence of residual horizontal pleiotropy

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