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Sustained stress stimuli that impair mitophagy lead to the accumulation of damaged mitochondria and the release of mtDNA, which, due to its bacterial-like CpG islands, is recognized as a damage-associated molecular pattern (DAMP) by the innate immune system, thereby activating inflammation and promoting chronic inflammatory diseases such as fibrosis and tumors (Zhong and Lemasters, 2018

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A twist of fate and an unfortunate coming together of a Mini Moke and a Spanish bus on the final selection weekend landed Bob and his brother Joe the prized gig

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