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Keywords: Herbal cigarette, Safety, Assessment, Mainstream smoke, Toxic component, Mutagenicity test INTRODUCTION Cigarettes smoke is a complex mixture of chemical components, many of which are known to be present in trace concentrations (1)

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The short answer to all of these questions is that we do not know, but there is reason to be concerned, because we do know that smoking is associated with increased risk of depression, marijuana use, binge drinking, and use of other drugs including opioids

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