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In a healthy volunteer study, ibuprofen 400 mg given once daily, administered 2 hours prior to immediate-release aspirin (81 mg) for 6 days, showed an interaction with the antiplatelet activity of aspirin as measured by % serum thromboxane B2 (TxB2) inhibition at 24 hours following the day-6 aspirin dose [53%]

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Microsomal Prostaglandin E Synthase-1 Gene Deletion Impairs Neuro-Immune Circuitry of the Cholinergic Anti-Inflammatory Pathway in Endotoxaemic Mouse Spleen

When youre drinking, youre already sending a toxic substance to your liver and making it work overtime to filter it out