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The correlation coefficients ranged from moderate (Figure S2ak) to no relationship (Figure S2lo) with almost no significant p -values

a , Trinucleotide contexts for the signatures extracted by the hierarchical Dirichlet process (HDP) (left) and MutationalPatterns non-negative matrix factorization (right)

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The participant is advised to reduce or stop drinking, educated about alcohol-related disorders, given a rationale to take medication, instructed on the importance of medication adherence and given information on the medications