In contrast, the pooled OR for cohort studies was 1.145 (95% CI: 0.8421.557), and the confidence interval included 1, suggesting that the association was not statistically significant in longitudinal data
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The interaction of AGEs with specific receptors, particularly the receptor for advanced glycation end-products (RAGE), triggers multiple intracellular signaling pathways, including NF-B, ERK1/2, p38, and MAPK, which in turn promote inflammatory responses and cellular stress (Yoshikawa et al., 2022
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