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In previous research, downregulation of GLT-1 and xCT protein expression was seen in the NAc of rats self-administering nicotine, and additionally restoration of GLT-1 expression was related to a reduction in nicotine self-administration ( Changes in glutamate homeostasis also seem to involve neuroinflammatory states

Sources: Stead LF, et al

The proportion buying cigarettes at street markets remained the same at under 10% over the six year period

On one hand, that seems obvious

And theres plenty of evidence that it does far more harm than good

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