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The conditional recommendations which the panel acknowledges need more research found that varenicline is superior to electric cigarettes as a treatment option, and that the combination of varenicline and a nicotine patch is more effective than using the drug alone

In human studies, impairment of flow-mediated dilation was reported after acute and chronic exposures to secondhand smoke and active smoking 11,12

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Food and Drug Administration (FDA) has approved: Four nicotine replacement therapies (NRT): transdermal patch* gum* lozenge* nasal spray Two non-nicotine medications: varenicline bupropion * available over-the-counter (OTC) and covered by Medicaid with a fiscal order and some health insurance plans with prescription requires prescription Combination Pharmacotherapy Not all smokers can quit with single-drug therapy

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