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However, research suggests that chronic passive smoke exposure may increase overall IgE levels and potentially lower the threshold at which allergic responses are triggered

Animal studies have shown that it suppresses respiratory irritation when animals are exposed to smoke and increases nicotine levels in the blood, Jordt says

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This leads further to hepatocellular inflammation, cell damage, hepatic stellate cell activation, mesangial cell activation, leading to the proliferation of fibrotic mediators, matrix metalloproteinases, and extracellular matrix proteins

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