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Damaged mtDNA can perpetuate a cycle of mitochondrial dysfunction and further ROS production, contributing to chronic inflammation ( In IPF, mitochondrial dysfunction, including reduced mtDNA copy number and impaired oxidative phosphorylation, has been implicated in epithelial cell injury and fibrosis ( 5 Mitochondrial dynamics and inflammation Fusion and fission are dynamic processes by which mitochondria undergo shape change and are central to maintaining mitochondrial integrity
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"Access to samples is a real challenge," Ramjeet explained, and a coordinated approach "will certainly accelerate access to Ebola tests for this current outbreak and build evidence for the future." The EOI is open to manufacturers of lab-based molecular kits, POC molecular assays, and antigen-based rapid diagnostic tests
The leader of the practitioners team, Dr