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It has been shown that the increase in insulin resistance was halted after nicotine replacement was stopped, and even improved during continuous weight gain, [78] implying that nicotine rather than weight gain may be responsible for the initial increase in insulin resistance observed in some smoking-related studies

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These results suggest that the ADHD PNE mouse model can recapitulate the key features of ADHD and may be used for further translational research in ADHD [82]