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The additional mucocutaneous features, including abnormal skin texture, easy bruising, hernias, piezogenic papules, light blue sclerae, uvular abnormalities, striae distensae/rubrae, keratosis pilaris/hyperkeratosis of extensor surfaces, absent/short lingual frenulum, resistance to local anesthetic drugs, and gingival inflammation/recession, are almost all shared not only with hEDS but also with other EDS subtypes and HCTDs [28, 29]

J Pathol 2006

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Studies have shown a synergistic relationship between asbestos and tobacco smoke in the causation of lung cancer

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