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The use of waterpipe tobacco has also grown in popularity recently, particularly in Europe and the Eastern Mediterranean 9

Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells

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Indeed, 85% of adults from 1829 years had tried vaping in 2018 and its consumption is directly correlated with advertisement exposure ( (accessed on 20 July 2018) [12])

Despite suggestions from both the scientific community and government agencies that nicotine may cause cardiometabolic harm long-term [18, 20], we know of no previously published trials that prospectively reported on beneficial cardiometabolic effects when quitting regular snus use