Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N -nitrosonornicotine enantiomers, N -nitrosopiperidine, and N -nitrosopyrrolidine
This reaction does not happen by chance
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US statistics reveal that smoking causes more deaths each year than HIV, illegal drug use, alcohol misuse, motor vehicle injuries and homicides combined
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