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she was addicted before anyone told her that cigarettes were bad for you

According to the Surgeon General , higher tobacco taxes can help reduce smoking rates in the US, especially when combined with anti-smoking campaigns

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One possible explanation provided by gene expression data in 2024 suggests that smoking is significantly associated with the upregulation of the cytokine receptor-like factor-1 (CRLF1) gene, which translates to actin alpha 2 (ACTA2+) smooth muscle cells, particularly found in carotid plaques

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