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This probably reflects substitution of trazodone for BZDs as sedative/hypnotics, especially after regulators and guidelines discouraged prescription of BZDs starting about 2012

Recheck serum estradiol 6 to 8 weeks after verified cessation and adjust patch dose downward if estradiol levels rise above the mid-follicular target range (approximately 40 to 100 pg/mL for symptomatic HRT)

However, this doesnt preclude the use of proxy measures of outcomes, such as changes in risk behaviours, such as smoking

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We generally do not consider nicotine to be a drug when, in fact, nicotine is a stimulant that speeds messages traveling between the brain and body

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