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Stage Two: Genetic Alterations Carcinogenic substances such as nitrosamines, polycyclic aromatic hydrocarbons (PAHs), and formaldehyde cause mutations in oncogenes and tumor suppressors (e.g., p53) present in the DNA of the mouth's lining

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That means IQOS cant compete with cigarettes on pricea huge disadvantage versus vaping products, which generally cost far less than cigarettes

Use of these products, particularly e-cigarettes, is increasing worldwide (Figure 4.3), especially among youth (see Tobacco Control, Figure 34.4)