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In: IARC Monographs on the Evaluation of Carcinogenic Risks in Humans

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First, we studied the associations of PGS and CHRNB2 pLOF-plus-missense burden with heavy smoking using logistic regression analysis, in which the heavy smoker phenotype was coded as the dependent variable (that is, outcome), and PGS, burden mask, an interaction term between PGS and burden mask and relevant covariates (the same as the ones used in the GWAS) were coded as independent variables (regression formula: heavy smoker PGS + burden mask + PGS burden mask + covariate 1 + covariate n )

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