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Statements Author contributions MB, AM, and CDF contributed to the manuscript drafts, and all authors approved the final version

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2) light smoking, defined as having smoked at least 100 cigarettes during the lifetime from the GWAS pipeline using Pheasant-derived variables from UK Biobank (GWAS ID=ukb-b-8133) ( 3) smoking initiation, as derived from a GWAS of Europeandescent individuals (GWAS ID=ieu-b-4877) 12

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