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The team recorded the molecular, epigenetic, and genetic changes of the cells over the course of the study

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[13] Toxicities [edit] When cannabis is smoked, blood levels of THC peak rapidly after a few minutes and then decline, although the psychotropic effects persist for longer

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[15] Around 1592, the Spanish galleon San Clemente brought 50 kilograms (110 lb) of tobacco seed to the Philippines over the Acapulco-Manila trade route