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For some people, symptoms never return

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10.1080/00952990.2016.1189927 Am J Drug Alcohol Abuse

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Bupropion Antidepressant that inhibits neuronal reuptake of dopamine and noradrenaline, and is a noncompetitive nicotine antagonist at nicotinic cholinergic receptors The drug is commenced while the person is still smoking, and a quitting date should be set in the second week of therapy (eg day 8) 300 mg /day- 12 wks Side effects: nausea, rashes, facial swelling, insomnia and dry mouth