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Pulmonary transfection of mtDNA by intratracheal instillation induced profound recruitment of neutrophils and expression of proinflammatory cytokines TNF- and KC (an IL-8 homologue) in C57BL/6 mice ( 2 by the mitochondria, leading to oxidation and inactivation of the ACO-2 substrate, and hence further accumulation of citrate to promote increased mtDNA synthesis

These findings indicate the opposite of what e-cigarette and vaping marketing is saying about their safety profile. Susan Cheng, MD, MPH, MMsc A recent study by the Food and Drug Administration found that 27.5% of high school students used e-cigarettes in 2019, compared to 20.8% in 2018

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Smoke inhalation is the primary cause of death in victims of indoor fires

The current evidence underscores the importance of continued research and caution in recommending e-cigarettes as a harm reduction strategy without comprehensive safety data