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Long-term fluoxetine side effects in women When women are on fluoxetine for six to 10 years or longer, they have reported long-term side effects, including: Restlessness Tension Agitation Sleep disturbances Low sex drive (which may persist even after discontinuation) They also report low estrogenwhich can trigger or contribute to painful vaginal intercourse, hot flashes, irregular periods, and morebut the data on fluoxetines impact on estrogen is conflicting

Addiction (Abingdon, England), 107(2), 263275

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Key takeaways Smoking is a significant risk factor for ED, as it damages blood vessels and reduces blood flow to the penis