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Both can also help address sexual dysfunction caused by a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs) Ritu Goel, MD, a Los Angeles-based board-certified child, adolescent, and adult integrative psychiatrist, says, Buspirone is used off-label sometimes to help with irritability in certain groups, such as patients with autism spectrum disorder, by targeting underlying anxiety. Theres also some evidence that buspirone helps with sleep when insomnia is linked to anxiety