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Januzzi, Jr., MD, FACC Chair, ACC Task Force on Expert Consensus Decision Pathways 1 Abstract Tobacco use, especially cigarette smoking, is a major risk factor for cardiovascular morbidity and mortality and is the leading preventable cause of death worldwide

Some of these additives, combined with naturally occurring compounds in tobacco, can contribute to cancer-causing substances

There are available transdermal patches on market, which are releasing nicotine with polymer matrix diffusion (82,83)

"WHO Framework Convention on Tobacco Control"

Each of these groups of chemicals has the potential for harmful health effects, especially if the user is exposed to these substances repeatedly (regularly) and over a long period of time

This process usually results in a smokier flavour which is preferred by certain users