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Prevalent diabetes mellitus was defined as fasting glucose 7.0 mmol/L or nonfasting glucose 11.1 mmol/L at study visits, and self-reported physician diagnosis of diabetes or the use of glucose-lowering medications at study visits or phone interviews before December 31, 2004

For patients with a creatinine clearance under 30 mL/min or experiencing end-stage renal disease, a reduced dose of 0.5 mg orally once daily was prescribed for the duration of therapy

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Facilitation of Smoke-free Workplaces: Many businesses implement smoke-free environments to promote employee health, reduce health insurance costs, and ensure non-smoking employees are not subjected to second-hand smoke