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In humans, it has a very short half-life and is rapidly metabolized by liver enzyme CYP2A6 into cotinine and OH-Cotinine, which in turn can be utilized as clinical biomarkers to assess smoking-status 55

Each cigarette features a premium blend of tobacco with carefully regulated nicotine content, delivering a smooth and satisfying draw with every puff

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This intervention could maintain the efficacy of e-cigarettes for traditional cigarette users looking to quit while also limiting their appeal to young adults

Addiction occurs when chronic exposure to nicotine induces the nervous system to adapt physiologically