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It is seen that there is an increase in respiratory system complaints such as cough and sputum production and the frequency of asthma attacks in electronic cigarette users

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[70] The pathophysiology of BED is not fully understood, but it is believed to involve dysfunctional dopaminergic reward circuitry along the cortico-striatal-thalamic-cortical loop

Prescription medications like opioids and sedatives are examples of substances such as alcohol, nicotine, and caffeine

The consistency of GLP-1 effectiveness across alcohol, opioids, cocaine, nicotine, and cannabis suggests these drugs may act on a shared vulnerability underlying addiction not on any single substance pathway