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Medications Pain relievers like aspirin, nonsteroidal antiinflammatories (NSAIDS) like ibuprofen (Advil and Motrin), blood pressure drugs called calcium channel blockers, antihistamines for allergies, benzodiazepines for anxiety (Xanax, Klonopin, Valium, etc.), certain antibiotics like tetracyclines, pain medications like opioids (Hydrocodone, Oxycontin, etc.), oral osteoporosis drugs like bisphosphonates (Boniva, Fosamax, etc.), and anticholinergic drugs used to treat a variety of disorders from overactive bladder to COPD can all cause acid reflux (3)

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