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Your symptoms change (they get a lot worse or become more common or ongoing)

Additionally, we found that children of mothers who had smoked in early pregnancy and before pregnancy also had a significantly increased risk of bronchial asthma at 3 years of age

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This is because nicotine decreases blood flow significantly, which can produce detrimental results in digit reimplantation during hand surgery

LlNDROOS, M., Kupari, M., Valvanne, J., Strandberg, T., Heikkil, J., & TlLVIS, R