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As a stimulant, nicotine quickly triggers the release of adrenaline (epinephrine) and dopamine, which increase heart rate, blood pressure, alertness, and feelings of pleasure or euphoria

Effects of a cannabinoid receptor (CB) 1 antagonist AM251 on behavioral sensitization to nicotine in a rat model of novelty-seeking behavior: correlation with hippocampal 5-HT

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Countries were also categorized into the six WHO regions: African Region (AFR), Regions of the Americas (AMR), Eastern Mediterranean Region (EMR), European Region (EUR), South-East Asian Region (SEAR), and Western Pacific Region (WPR) 13