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6 Lead to vomiting and nausea if a mother is smoking 20 cigarettes or more daily 7 and may cause diarrhoea and increase a babys heart rate (Fisher, 2006)

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Given the possibility that some antidepressants are metabolized by CYP induced or inhibited by substances in tobacco, their identification can be a guide for drug initial choice in smoking patients, allowing a more accurate antidepressant selection and consequently improving the pharmacologic treatment of depression in smokers