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Consequently, it is difficult to make generalizations about efficacy for cessation based on clinical trials involving a particular e-cigarette, and there is presently inadequate evidence to conclude that e-cigarettes, in general, increase smoking cessation

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Mutual Reinforcement : Both substances influence dopamine release, potentially reinforcing each others effects and increasing the likelihood of co-use

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At the same time, at lower concentrations, this value showed little association (79)